Obesity and sarcopenic obesity characterized by low-grade inflammation are associated with increased risk for major depression in women

Julie A Pasco; Michael Berk; Brenda Penninx; Natalie K Hyde; Kara L Holloway-Kew; Emma C West; Mark A Kotowicz; Kara B Anderson; Adrienne O'Neil; Pamela G Rufus-Membere; Lana J Williams

Journal article

Obesity and sarcopenic obesity characterized by low-grade inflammation are associated with increased risk for major depression in women

Julie A Pasco, Michael Berk, Brenda Penninx, Natalie K Hyde, Kara L Holloway-Kew, Emma C West, Mark A Kotowicz, Kara B Anderson, Adrienne O'Neil, Pamela G Rufus-Membere, Lana J Williams

Frontiers in Nutrition | Frontiers Media S.A. | Published : 2023

DOI: 10.3389/fnut.2023.1222019

Abstract

Background: We aimed to determine women’s risk of major depressive disorder (MDD) in relation to obesity phenotypes characterized by levels of circulating high-sensitivity C-reactive protein (hsCRP). Methods: This population-based retrospective cohort study comprised 808 women (ages 20–84 y) recruited 1994–1997 and followed for a median 16.1 y (IQR 11.9–16.8). At baseline, body fat and lean tissue mass were measured by whole body dual-energy x-ray absorptiometry (DXA). Obesity was identified as high fat mass index (>12.9 kg/m2), body fat percentage (≥35%) and body mass index (≥30 kg/m2); sarcopenic obesity referred to a high ratio fat mass/fat-free mass (≥0.80). Systemic inflammation was ope..

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University of Melbourne Researchers

Michael Berk Author

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Awarded by Deakin University Postgraduate Industry Research Scholarship

Funding Acknowledgements

The authors thank Dr. Hans Schneider for analyzing serum samples for hsCRP.r This work was supported by the Victorian Health Promotion Foundation (VHPF) and the National Health and Medical Research Council (NHMRC) (251638, 454356, 509103, and 628582). MB was supported by a NHMRC Senior Principal Research Fellowship and Leadership 3 Investigator grant (1156072 and 2017131); NH by an Executive Dean's Postdoctoral Research Fellowship (Deakin); KH-K by an Alfred Deakin Postdoctoral Research Fellowship; EW and KA by Australian Government Research Training Program Scholarships; AO'N by an NHMRC Emerging Leader 2 Fellowship (2009295); PR-M by a Deakin University Postgraduate Industry Research Scholarship; and LW by a NHMRC Emerging Leadership Fellowship (1174060).